Prognosis and Epidemiology
• Approximately 40 percent of patients with PCOS have insulin resistance that is independent of body weight. These women are at an increased risk for type 2 diabetes mellitus and consequent cardiovascular complications.
• Patients with PCOS are also at increased risk for endometrial hyperplasia and carcinoma. The chronic anovulation in PCOS leads to constant endometrial stimulation with estrogen and this increases the risk of endometrial hyperplasia and carcinoma.
• In the US, PCOS is one of the most common endocrine disorders of reproductive-age women, with a prevalence of 4-12 percent.