Pathophysiology of Bipolar Disorder
Clinical research has attempted to uncover the possible mechanism underlying pathophysiology of bipolar disorder. Based on the research, the scientists believe that the depressive or manic behavior seen in people with bipolar disorder is caused due to the altered synthesis, storage, or release of the neurotransmitters in the brain.
The levels of neurotransmitters such as norepinephrine, serotonin and dopamine are lower during the depressive episode and higher during manic episode. Importantly the concentrations of these neurotransmitters are much lower during depression that occurs in bipolar disorder than the unipolar depression.
Imbalance of Neurotransmitters in Bipolar Disorder